🧠 Why are PK simulations under fed-state conditions still so challenging?

❗ Despite advances in physiologically based modeling, many approaches still assume homogeneous mixing of drug and gastric contents. Yet, real clinical data tell a different story—irregular plasma profiles, multiple secondary peaks, prolonged lag times, or unexpectedly early Cmax values.

🤔 These phenomena point to a much more complex reality: non-uniform drug distribution in the stomach and the critical role of the Magenstrasse (stomach road), especially in the presence of gastric secretions and repeated water intake.

📅 Join the rapid-fire session on Thursday, April 23rd to hear the lecture:

👉 „Cracking the fed state code: A Python-based model and application for mechanistic exploration of irregular and variable plasma concentration profiles caused by stomach road and multiple water administrations.”

Looking forward to insightful discussions and new perspectives on tackling fed-state complexity in PK modeling!

Registration and program: https://pbpkconference.org/