The successful development of oral medicinal products necessitates a comprehensive understanding of molecular and biomolecular stability within the highly variable physicochemical landscape of the gastrointestinal tract. Physiolution provides a specialized suite of analytical methodologies designed to evaluate the suitability of APIs for oral delivery and to identify critical factors impacting their chemical stability and biological activity by providing a unique Biorelevant Analytical Framework.
Our experimental protocols are designed to simulate the stressors of the GI environment, providing a high-resolution assessment of molecular integrity. Key services include:
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These investigations yield the foundational data required to transition from empirical testing to physiology-driven formulation development. By quantifying molecular liabilities early in the pipeline, Physiolution enables:
We are a multidisciplinary team of scientists and engineers pioneering the development of biopredictive dissolution testers and PK/PD tools. By integrating laboratory expertise with advanced engineering and analytics, we bring predictability to the most complex challenges in oral drug development.
We provide a physiologically oriented device that enables biorelevant simulation of intestinal pH gradients without altering the volume or ionic strength of the simulated intestinal media. Its operation is based on gaseous pH adjustment of hydrogen carbonate—the most biologically relevant buffering system in the human gut.
We reduce formulation-related frustration, costs and uncertainty by moving key anwers from late-stage clinical trials into an earlier, precise biopredictive stage of development.
We gratefully acknowledge the support of:
