At Physiolution, our pharmacokinetic (PK) simulations act as the vital link between laboratory data and clinical reality. We help drug developers navigate the In Vivo Gap by transforming biopredictive data into actionable simulations and clinical insights.
Modern drug development generates vast amounts of data that are often siloed. We provide a thorough analysis of complex study results and experimental data, identifying the underlying patterns that dictate formulation success. Our holistic approach ensures that no critical detail is overlooked in the transition from bench to bedside.
We utilize sophisticated simulation workflows built upon our proprietary biopredictive in vitro data. By mimicking the actual mechanical and chemical stressors of the GI tract, our simulations extract meaningful insights into how a formulation will perform in a living system, allowing for precise optimization long before the first human dose.
In clinical reality, means are meaningless Standardized average models often fail to predict the failures seen in outliers. We incorporate population-level variability into our simulations, reflecting real-life conditions more closely. This allows us to assess the robustness of your formulation across a wide range of patient phenotypes.
Our methodology is built on a rigorous, research-based foundation. Our models are continuously refined and validated against clinically relevant examples. We believe in the open exchange of innovation. Our team regularly publishes findings and methodological advancements in top-tier, peer-reviewed research journals, ensuring our clients benefit from industry-leading, scrutinized science.
Main product used in this task/job
We provide a physiologically oriented device that enables biorelevant simulation of intestinal pH gradients without altering the volume or ionic strength of the simulated intestinal media. Its operation is based on gaseous pH adjustment of hydrogen carbonate—the most biologically relevant buffering system in the human gut.
Simulating GI factors such as pH and enzymatic activity allows us to assess molecular suitability for oral delivery and support physiology-driven formulation development.
We gratefully acknowledge the support of:
